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Possible reasons include the Washington State University patent holders not finding a pharmaceutical company willing to invest in development, the cancer biology concern with c-Met activation making development companies cautious, the preclinical effect sizes in rats not justifying the expense and risk of human trials, or other factors specific to drug development economics

Efficacy in Treating B12 Deficiency: Methylcobalamin is a naturally occurring form of Vitamin B12, while Cyanocobalamin is a synthetic form