Blumenreich M, Andreeff M , Chou TC, Wittes R, Clarkson B, Young C
To develop cardiac insulin resistance, major factors such as hyperglycemia, hyperlipidemia, oxidative stress, inappropriate activation of sympathetic nervous system and the renin-angiotensin II-aldosterone system (RAAS), and dysregulated secretion of adipokines/cytokines are all significant contributors [139]
I think this goes back to what you started to talk about with micronutrient deficiencies because if we don't have enough minerals, we can't build bone
References Lillys selective amylin agonist, eloralintide, demonstrated meaningful weight loss and favorable tolerability in a Phase 2 study of adults with obesity or overweight, 06 November 2025, Lilly, Briere DA, et al, Eloralintide (LY3841136), a novel amylin receptor agonist for the treatment of obesity: From discovery to clinical proof of concept
Assess peptide stability and degradation kinetics under controlled experimental conditions
Cobalamin works with folic acid to help prevent neural tube defects
