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In a model of amyotrophic lateral sclerosis (ALS) caused by C9orf72 gene mutations, the pathogenic poly-dipeptide GA50 directly binds to and inhibits SQOR, leading to excessive NLRP3 inflammasome activation in microglia and consequent mitochondrial dysfunction ( A growing body of preclinical work supports this strategy: boosting SQOR activity or reducing H 2 S can protect the nervous system

Additionally, pregnant women are experiencing exposure to an increasing number of dangerous industrial chemicals

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10.1242/dev.01861 61 YagiM.MagalE.ShengZ.AngK

theta GR-converting operon were significantly correlated with conversion percent: B