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Scrambled siRNA was used as a control

Although L-tyrosine is a non-essential amino acid that can be synthesized endogenously from phenylalanine via the enzyme phenylalanine hydroxylase, its synthesis may become insufficient under conditions of physiological stress, rapid growth, or limited phenylalanine availability [71]

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Given the intricate links between O-GlcNAcylation and neurodevelopmental diseases, further investigation into the role of this modification in these disorders is crucial for understanding their pathogenesis and developing effective therapeutic strategies