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The weight loss effect depends specifically on AMY1R and AMY3R activation, as confirmed by a study in eBioMedicine that showed cagrilintide lowers body weight through these specific receptor subtypes in the brainstem

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Adems, el uso de cido valproico con o sin otros anticonvulsivos puede causar hepatotoxicidad y aumentar las concentraciones de amonaco en plasma, lo que conduce a una encefalopata