Adults typically need 2.4 mcg per day (which goes up to 2.6 and 2.8 mcg per day if pregnant or breastfeeding, respectively)
But only a maximum of 5mcg of B12 enters the bile every day (according to "Advanced Haematology" 7th edition textbook, page 60), so it seems that only an additional 5mcg would be lost daily if none was recovered
When you start with a 100 mcg B12 injection, you usually take it once a month
The frequency of injections depends on individual needs and medical advice, but our recommended protocol is twice a week
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According to NICE Clinical Knowledge Summaries and the British National Formulary , the standard treatment is intramuscular injections of 1,000 mcg (1 mg) hydroxocobalamin