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In smokers, a single dose of the xanthine oxidase inhibitor allopurinol restores the acetylcholine-induced endothelium-dependent relaxation response in forearm arteries to nonsmoker levels but does not affect the endothelium-dependent relaxation response in nonsmokers [73]

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In a recent study of 106 healthy smokers, a significant increase in cortisol concentrations was found following exposure to the stressor in daily smokers, occasional smokers, and nonsmokers, and the magnitude of the cortisol increase in the daily smoker group was lower than in the occasional smokers and nonsmoker groups [110]

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[31] The smoking age was raised in Connecticut from 18 to 21 in 2019 two months prior to the passage of the federal Tobacco 21 law