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In turn, ROS and pro-inflammatory mediators such as IL-6 and IFN have been reported to increase chemotherapy resistance by up-regulating anti-apoptotic genes, stimulating stemness, increasing repair of damaged DNA, and increasing drug efflux 29,41,63

Fourth, heaviest smokers (in terms of early initiation or duration of smoking) may have died before the study began, potentially biasing our observed associations towards the null

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About this article Cite this article Sundaresan, I., Palanisamy, N