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In obesity, NNMT activity is unusually high in fat cells, which means a lot of nicotinamide gets thrown out before it can be turned into NAD+
It is an intracellular metabolic-enzyme modulator, which is why its research read-outs are things like NAD+ levels and adipocyte gene expression, not how full you feel. That mechanistic distinction is the single most important thing to understand before looking at any dose number
For one B12, when used in combination with folate and B6, can reduce the risk of breast cancer
[8] Early small-scale research suggested it may stimulate lipolysis (the breakdown of fat) and inhibit lipogenesis (fat storage), with preliminary data indicating it may not significantly affect blood glucose or insulin-like growth factor-1 (IGF-1) levels
For physiological reasons, dietary vitamin B12 generally cannot cause hypercobalaminemia
