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Additionally, sensitivity analyses showed robust association and no unbalanced pleiotropy

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Additionally, DSIP appears to be regulated by glucocorticoids, and its signaling may interact with the MAPK cascade through homology with glucocorticoid-induced leucine zipper (GILZ), suggesting potential roles in cellular stress responses

compare iHLO protein profiles with native liver tissue and highlighted enrichment of detoxification pathways in both systems, emphasizing the relevance of organoids for metabolically intensive applications 15