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Novel aptamer-nanoparticle bioconjugates enhances delivery of anticancer drug to MUC1-positive cancer cells in vitro
Hallmarks of trained immunity at the HSC level include increased HSC proliferation, expansion of myeloid-biased multipotent progenitor 3 (MPP3), and myeloid-biased differentiation 14,15
Cell 187 , 43734388.e15 (2024)
Ongoing clinical research focuses on optimizing brain-targeted delivery (e.g., NCT05022472, a trial evaluating DFO-gold nanoparticle conjugates) and developing structural analogs (e.g., CNB-001) to enhance efficacy while reducing off-target effects