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Non-coding RNAs in GI cancers: from cancer hallmarks to clinical utility

These may act as signaling metabolites with anti-tumor effects by engaging G-protein receptors and inhibiting class-I histone deacetylases, altering gene expression, and dampening PI3KAKT-mTOR signaling 354,355

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The tirzepatide vs semaglutide dosage comparison shows tirzepatide outperforms semaglutide by 5-7 percentage points in weight loss

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Secondary outcomes The secondary outcomes are as follows: type 2 diabetes, glucose, HbA1c, insulin, lipid profile (LDL-cholesterol, HDL-cholesterol, triglycerides and apolipoprotein B), systolic blood pressure, diastolic blood pressure, and body mass index (BMI), which are well-established risk factors for CVD in clinical practice, or recently identified to be related to CVD in MR, such as apolipoprotein B [30, 31]