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In addition, the hypoxic microenvironment caused by impaired oxygen delivery due to abnormal vascular systems affects drug efficacy

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doi: 10.3390/antibiotics12020274, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 346

237,304,305,306,307,308 Endothelial dysfunction characterized by impaired nitrogen oxide-mediated vasodilatation is a key event in the development of atherosclerosis