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For instance, some products of the cholesterol synthesis pathway, such as geranylgeranyl pyrophosphate (GGP) and farnesyl pyrophosphate (FPP), are included in the prenylation and subsequent activation of the small GTPase group of signaling molecules including RhoA with its effector Rho kinase [72]

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We confirmed that 5FU treatment over 72 h continues to promote accumulation of 5FU within cells (Fig

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