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The activation of D14 is initiated by the intact SL molecule, which induces a destabilized conformation in D14 by interfering with the formation of its catalytic triad, rather than by its hydrolysis intermediates or products 24

Specifically, it completes schizont development within the mononuclear phagocyte system, thereby circumventing erythrocyte immune surveillance

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In the absence of iron, and subsequent depletion of heme, the HRI kinase is activated in red blood cells 184,185