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TICs maintain lower intracellular ROS levels than other cancer cells within the tumor, primarily through the accumulation of ROS scavengers like glutathione and the overexpression of Gclm and glutathione synthetase, the enzymes necessary for its synthesis, as shown in breast and liver cancer stem cells [18, 20]

In the group of patients without acute pancreatitis no difference was found between T=0 and T=48 hours, but a difference was found in the increase of the values at the two points in time, in the group of patients with acute pancreatitis the change was bigger (Wilcoxon rank sum test 1 sided, p=0.014)

Mitochondrial fatty acid oxidation generates acetyl-CoA, a major substrate for the TCA cycle

Immunogenicity of Biotherapeutics: Causes and Association with Posttranslational Modifications

Chronic diseases often have immune dysfunction

This ensures the highest level of quality and sterility for our patients