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Cellular autophagy and cell death In DPN, hyperglycemia impairs autophagy by inhibiting key autophagy-related proteins, resulting in the accumulation of dysfunctional mitochondria and protein aggregates

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This inhibition parallels the effects observed with indomethacin, a conventional COX-2 inhibitor, and underscores BVs capability to attenuate inflammatory mediators within synoviocytes of RA patients (84, 90)

It has been shown that daily supplementation of adults with 670 mg of vitamin E for 3 months suppressed the vitamin K-dependent factor important in the coagulation cascade

So thats why Lyme treatments will put a lid on Bartonella, but not get rid of it