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Diagnoses included osteoarthritis (55.5 percent), chronic low back pain (51.5 percent), and neuropathic pain (24.8 percent, primarily in the feet)

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Specifically, eligible studies included participants (P) with a confirmed diagnosis of vitamin B12 deficiency, interventions (I) involving oral or sublingual vitamin B12 administration, comparators (C) using intramuscular supplementation, and outcomes (O) reporting changes in serum vitamin B12 or homocysteine levels

Proper storage conditions according to ICH guidelines were also evaluated and finally aqueous state degradation kinetics was studied and the predominant model was proposed