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Unfortunately, better controlled, double-blind randomized clinical trials performed by the Mayo Clinic failed to show any positive effects of high dose vitamin C in cancer patients

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The mobile phase, consisting of HPLC-grade water and acetonitrile in a 45:55 (v/v) ratio, was delivered at a flow rate of 0.8 mL/min

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Both studies met the primary endpoint of treatment success as determined by a score of clear or almost clear on the validated Investigator Global Assessment-Atopic Dermatitis scale, alongside a two-grade improvement at four weeks