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As shown in Figure 2, it consists of three subunits: 1) a sensor protein (Nod-like receptor pyrin-domain containing protein 3), 2) an adaptor protein (apoptosis-associated speck-like protein (ASC)) and 3) pro-inflammatory Caspase-1 [80]

Proc Natl Acad Sci U S A 94:1036710372

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Almost all of the above cited studies have appeared in the past five years, with the majority published in the last two

Table SIII contains the sequences of the primers utilized

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