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[54] presented evidence that in natural S

Several direct targets of valproate have been discovered including the mitochondrial enzymes, succinate semialdehyde dehydrogenase and long-chain fatty acid-CoA ligase-4, as well as the family of nuclear-localised histone deacetylases that are involved in epigenetic regulation of gene expression [179,180,181]

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Critically, immunoregulatory pathways are compromised

Vit B12 pathophysiological fingerprints in PD Vit B12 and neural pathways in PD Vit B12 has been touted as a crucial component of the cholinergic pathway within the brain in several neurodegenerative diseases (El-Mezayen et al