They should be sourced from licensed compounding pharmacies, not unregulated online vendors, and used with appropriate lab monitoring
They'll most likely want to do routine bloodwork to check your B12 levels
Once you are done with this frequency, you may start administering vitamin injections once every month
Neomycin, colchicine, para-aminosalicylic acid, or excessive alcohol intake longer than two weeks may cause malabsorption of vitamin B12. Chloramphenicol and other drugs having bone marrow suppressant properties may cause a lack of therapeutic response to vitamin B12
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It can also develop from poor B12 absorption, because some people are not able to absorb it well