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And thus, there is desperate need to elucidate the neurological effects of APAP in elderly hosts, who are likely to be exposed since an earlier age 6,33,34 and correspond to the subgroup at highest risk of various relevant factors as noted earlier (APAP overexposure 18 , NAPQI accumulation 19 , and vulnerable to brain abnormalities 20 )

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Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll-like receptors 7 and 8

PubMed Central, Pera-Kajn, Joanna, et al

SF3B1 association with chromatin determines splicing outcomes