doi: 10.1080/14786419.2017.1299727 58
GSH maintains the antioxidant function of GPX4a central ferroptosis regulator that catalyzes GSH oxidation to oxidized glutathione (GSSG) while reducing cytotoxic lipid peroxides to non-toxic alcohols (L-OH), thereby mitigating oxidative damage ( blocks cystine import, disrupting GSH synthesis, impairing cellular antioxidant capacity, and inactivating GPX4, ultimately driving intracellular ROS accumulation and cell death
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Regulatory t cells restrain pathogenic t helper cells during skin inflammation
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de Sa Coutinho D, et al