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Radiotherapy increases tumor cell ferroptosis susceptibility, significantly inducing the expression of long-chain acyl-CoA synthetase 4 (ACSL4) and the ferroptosis inhibitors SLC7A11 and GPX4, thereby effectively suppressing tumor growth (109)

Collectively, these peptides accelerate repair processes, reduce inflammation, and enhance tissue regeneration at cellular and molecular levels

Mechanistically, Iso reduced ROS and MDA levels, enhanced SOD and CAT activity, and suppressed the NOX4/ROS/NF-B pathway by promoting Nrf2 nuclear translocation (Dai et al., 2018)

V., Brandsma, C

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