In patients who may be susceptible to the intracranial effects of CO2 retention (e.g., those with evidence of increased intracranial pressure or brain tumors), hydrocodone bitartrate and acetaminophen tablets may reduce respiratory drive, and the resultant CO2 retention can further increase intracranial pressure
Hardeland, R
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avoid vigorous vortexing or repeated freezethaw cycles, and protect reconstituted vials from prolonged light exposure (store in amber containers when needed)
