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Proper assessment of the patient, proper prescribing practices, periodic re-evaluation of therapy, and proper dispensing and storage are appropriate measures that help to limit abuse of opioid drugs

Patients with inflammatory bowel disease, diverticular disease, haemorrhoids, recent colorectal surgery, cardiovascular conditions, pregnancy, severe renal or cardiac impairment, coagulopathy, or recent pelvic radiotherapy face heightened risks

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The investigator was blinded to the group allocation during the experiment

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