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In studies of human glioblastoma, the absence of exogenous Gln significantly reduces glutamate levels, resulting in the conversion of the dimer GLS1 into a self-assembled, extremely low Km filamentous polymer that further depletes intracellular Gln
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In conclusion, although FSP1 inhibitors demonstrated tremendous potential in tumor therapy, further research is necessary to address existing challenges and optimize the application of these compounds in clinical practice