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Both lipoic acid and dihydrolipoic acid have been found to inhibit copper- and iron-mediated oxidative damage in the test tube (22, 23) and to inhibit excess iron and copper accumulation in animal models (24, 25)

When we compared the synthesized compound 2 ( 2 syn ) to its counterpart formed through the photo-oxidation of compound 1 ( 2 irr ), we observed no differences in their optical properties and stereochemistry (Supplementary Figs

Le, T.M., et al., Gamma-glutamylcysteine ameliorates oxidative injury in neurons and astrocytes in vitro and increases brain glutathione in vivo

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This discrepancy suggests that factors beyond connexins may contribute to hepsin's protective role