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nAChRs are ligand-gated ion channels composed of five membrane-spanning subunits that combine to form a functional receptor ( N -nitrosamines (TSNA) and cotinine may also bind to nAChRs ( The binding of nicotine to nAChR in the brain is involved in the rewarding effects of nicotine and in the adaptations that occur in response to chronic exposure, which give rise to dependence and to withdrawal responses

As the highest point on the boat, engineers focused heavily on keeping the deck lightweight to optimize performance dynamics