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16 Nicotine and other components of cigarette smoke induce microcirculation alterations with consequent vasoconstriction and hypoxyemia 17 , 18 and exhibit an inhibitory effect on the chemotaxis of neutrophils and lymphocytes

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PLoS One 13(7):e0198681 Carll AP, Arab C, Salatini R, Miles MD, Nystoriak MA, Fulghum KL et al (2022) E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice