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In reality, this level of Ni inhalation is not likely to induce serious health risks in most people, given that RELs and PELs are generally derived using overly cautious principles of safety, nevertheless, Ni is a known potential carcinogen (United States Department of Labor, 2013) and the pathophysiological responses to Ni inhalation is not the same for all individuals

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Remove the patch before bed if you can't sleep