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A 2019 review in Aging Cell noted that metformin reduced circulating TNF-alpha by 17% and IL-6 by 24% in a pooled analysis of 664 patients with type 2 diabetes across four randomized controlled trials [9]

doi: 10.1021/jf9903298, PMID: [DOI] [PubMed] [Google Scholar] 94

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Results: At 37C, T cells exhibited active lamellipodia-driven migration

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