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Cells were cultured in a 96-well plate for 6 or 7 days to establish senescence response, as previously described (Supplementary Table 8)

doi: 10.1111/jog.15009 89 ZhuHJiaZMisraBRZhangLCaoZYamamotoMet al

This hormonal effect accounts for sexual characteristics changes in immune function, and the higher susceptibility of women to autoimmune diseases like SLE ( It will be crucial to distinguish the interplay of gut microbiota and the sex hormones as it can potentially unlock the mechanisms of higher susceptibility of females to SLE and also unveil novel avenues of therapeutic intervention by manipulation of the gut microbiome for controlling disease course ( 3 Probiotics and systemic lupus erythematosus Probiotics are live microorganisms significant for their role in immunomodulation in SLE patients, as they restore gut microbiota balance and enhance immune function

Therefore, several techniques have been developed for increasing the homing of therapeutic products to the brain parenchyma ( Figure 2 )

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These factors can stem from the tumour cells themselves, the surrounding tumour microenvironment or systemic influences 1