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Ferroptosis is driven by lipid peroxidation, relying on Fe 2+ -mediated Fenton reactions, and occurs in close association with dysregulation of the SLC7A11/GSH/GPX4 antioxidant system

1 Introduction With an aging global population, it is estimated that 2.2 billion people worldwide are suffering from visual dysfunction, which severely impedes the individuals quality of life and poses threats to public health ( Ferroptosis, a term initially coined by Dixon in 2012, is a distinctive form of RCD featured by the iron-dependent lethal aggregation of lipid peroxides located at the cell membrane ( Figure 1 )

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[2] Kalra, N