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To the best of our knowledge, the present study is the first to show that uric acid affected NO levels in VSMCs in a dose- and time-independent manner, while also providing comprehensive evidence that uric acid increased superoxide anion levels at 1, 3, 6, 12 and 24 h, with a less pronounced increase at 3 h compared with the other time points, and its dose-dependent effects on protein carbonyl levels

NaBPC157 can be used for the treatment of various pain disturbances as well as in conditions followed by somatosensory neuron function impairment

Ethics declarations Conflict of interest The author declares no competing interests

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls