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Traditional peptides like insulin or GLP-1 agonists have near-zero oral bioavailabilityproteases in the stomach and small intestine cleave peptide bonds within minutes, and what little survives is metabolised by cytochrome P450 enzymes in the liver before reaching systemic circulation

Fur-like Proteins: Beyond the Ferric Uptake Regulator (Fur) Paralog

Cell Stem Cell 15 , 410415 (2014)

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[6] [8] Animal studies [edit] GPX1 helps to prevent cardiac dysfunction after ischemia-reperfusion injuries

It has also been found that ADNP is involved in histone methylation [346] and acetylation [347] upon interaction with proteins, such as the histone deacetylase sirtuin 1 (SIRT1), which regulates the transcriptional activity and epigenesis [293]